LMNA and dilated cardiomyopathy: Mutations in these proteins lead to a variety of diseases, collectively called laminopathies, including partial lipodystrophy, mandibulolacral dysplasia (MAD), dilated cardiomyopathy, autosomal-dominant limb-girdle muscular dystrophy type 1B (LGMD1B), Charcot-Marie-Tooth neuropathy type 2B1 (CMT2B1), restrictive dermopathy, Hutchinson-Gilford progeria, Werner's syndrome and Emery-Dreifuss muscular dystrophy (EDMD) (Capell and Collins, 2006).