Our analysis of the patient fibroblast lines showed abnormalities in the nuclear structure with concomitant mislocalisation of Nesprins, Emerin, LaminA/C and LaminB1 at the NE, and alterations in adhesion, migration and further physiological properties such as senescence and stress sensitivity which are in general characteristic for fibroblasts from laminopathies. Here, EMD is linked to laminopathy.