Loss of Nesprin-2 has been shown to cause severe nuclear morphology defects in LMNA S143F progeria cells (Kandert et al., 2007) and Nesprin-2 knockout mice show an increase in nuclear volume (Lüke et al., 2008) suggesting that loss of Nesprin-2 Giant from the NE results in nuclear morphology defects. The gene discussed is SYNE2; the disease is progeroid syndrome.