It could be speculated that the association between EGFR+ CTCs and luminal BC patients is explained, in part, by an increase of cancer cells expressing EGFR involved in the paracrine loop in which epidermal growth factor produced by tumor-associated macrophages increases the invasiveness and migration of BC cells that express EGFR [7,8], although EGFR expression has been widely related to lower HR levels, higher proliferation, genomic instability, and HER2 overexpression [42]. This evidence concerns the gene EGFR and breast cancer.