PADI4 and arthritic joint disease: Because the K/BxN model is neutrophil dependent, PAD4 activity is required for NET formation and PAD4 overexpression correlates with rheumatoid arthritis in patients, we sought to determine the extent to which PAD4 would contribute to the effector phase of arthritis using the K/BxN-serum transfer model [20,25,27,36].