Aeberli and colleagues, however, reported no direct evidence for the impact of endogenous MIF on transcriptional regulation of IκBα by dexamethasone [12] To further clarify the mechanisms underlying recombinant MIF, different concentrations were added to PBMC cultures from SS SLE patients followed by treatment with dexamethasone. The gene discussed is MIF; the disease is systemic lupus erythematosus.