There are some good reasons to believe that (1) VEGF is a critical cytokine in tumor angiogenesis and a target for therapy [27], (2) tumor growth is intensified by VEGF, which binds to endothelial cells and initiates the process of new blood vessel formation [28], (3) high preoperative blood VEGF levels are associated with more advanced disease and a worse prognosis in lung cancer patients [29, 30]. The gene discussed is VEGFA; the disease is lung cancer.