The rate of animals developing disease, however, is substantially lower when p14/Rip-gp transgenic mice are challenged with the low agonistic peptide LCMV-LF6 (diabetes rate <50%), whereas injection of cblb-deficient animals with this low agonistic peptide induced rapid onset of diabetes paralleled by an enhanced CTL function [25]. The gene discussed is CBLB; the disease is diabetes mellitus.