LAT and disease arising from reactivation of latent virus: However, by experiments in acute and latent ganglionic infection in mice and lytic infection in Vero cells infected with wide-type or LAT deletion mutant HSV-1, Kramer et al. found that LAT deletion mutants establish and maintain latent infections and concluded that microRNAs are not essential for latency in mouse trigeminal ganglia, but may help promote it [17].