IFNL3 and hepatitis C virus infection: In 2009, 3 genome-wide association studies (GWASs) demonstrated an impact of single-nucleotide polymorphisms (SNPs) in the spanning region between IL28B and IL28A on interferon-based hepatitis C clearance [7][8][9], implicating rs12979860 and rs8099917 as the strongest genetic determinants of SVR.