Recently, the American Association for the Study of Liver Diseases (AASLD) included IL28B testing in its guidelines [14], with a recommendation grade of Class 2a and Level B. Several methods, such as DNA sequencing, Taqman® allelic discrimination assay, pyrosequencing, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and allele-specific PCR, can be applied for genotyping of SNPs, such as IL28B polymorphisms [15]. The gene discussed is IFNL3; the disease is liver disorder.