INS and type 2 diabetes mellitus: They reported that early development of type 2 diabetes mellitus, lower resting metabolic rate, abdominal obesity, and resistance to insulin were associated with persons homozygous for the variant allele (Arg/Arg) compared to those homozygous for the wild-type allele (Trp/Trp) and those heterozygous for the variant allele (Trp/Arg) [2–6].