Hedgehog pathway alterations—mainly loss of function of Ptch and SuFu or activating mutations in Smo, Hh, or Gli—are thought to be oncogenic in a considerable number of other cancers (gliomas, breast, lung, prostate, ovarian, colon, and endometrial carcinomas, multiple myeloma, and chronic myeloid leukaemia, among others) [26]. The gene discussed is GLI1; the disease is cancer.