Such strategy is reasonable especially in the light of recent findings made by Erkizan and coworkers [130] who identified a small molecule inhibitor of EWS-FLI1 fusion transcript interaction with RNA helicase A (RHA), which is important in the oncogenesis of Ewing's sarcoma family tumors (ESFTs). The gene discussed is DHX9; the disease is Ewing sarcoma/peripheral primitive neuroectodermal tumor.