MYOC expression is greatest in the TM [34] and is dramatically induced by dexamethasone, a glucocorticoid [17], in human TM cultures, leading to the original name for the MYOC protein of TM inducible glucocorticoid response element (TIGR) [35] and supporting the concept that MYOC may be responsible in part for steroid-induced glaucoma [36]. Here, MYOC is linked to glaucoma.