PAX6 and microphthalmia: For example, Meis homeobox 2 (MEIS2) modulates PAX6 transcription activity, and in madaka fish morpholino-mediated ablation of miR-204 targeting Meis2 results in an eye phenotype characterized by microphthalmia, abnormal lens formation, and altered dorsoventral patterning of the retina [38].