Therefore, in this report we analyzed, according to our best knowledge for the first time in so large and homogenous with respect to tumor clinical stage and adjuvant chemotherapy type, the relation between MVD or p53 status and DFS in the group of patients with T1-T2, N1-N2, M0 breast carcinoma, treated with anthracyclines in adjuvant setting. The gene discussed is TP53; the disease is neoplasm.