In a very recent study, by blocking HPV E6-mediated p53 degradation to activate the transcription of NOXA, RITA (a small-molecule reactivation of p53 and induction of tumor cell apoptosis) induced apoptosis in multiple cancer cells containing HPV16 and substantially suppressed the growth of cervical carcinoma xenografts in vivo [29]. This evidence concerns the gene PMAIP1 and neoplasm.