By using the group with the NOXA rs9957673 CC genotype and HPV16 seronegativity as reference, those with the CT/TT genotypes and HPV16 seronegativity did not show association with increased SCCHN risk (OR = 1.0; 95% CI,0.7-1.4); however, those with the CC genotype and HPV16 seropositivity had a 2.4-fold increased SCCHN risk (95% CI, 1.4-4.0), and those with the CT/TT genotypes and HPV16 seropositivity had a 3.6-fold increased SCCHN risk (95% CI,1.9-6.8). The gene discussed is PMAIP1; the disease is head and neck squamous cell carcinoma.