In consistence with our previously published studies in which HPV16 and genetic variants of p53 pathway genes, such as p53 or MDM2, may have interactive effects on risk of oropharyngeal cancer, particularly in never smokers and never drinkers [27,28], we also found in current study more pronounced modification effects of NOXA and MCL1 variants on the risk associated with HPV16 seropositivity for oropharyngeal cancer, particularly in never smokers and never drinkers. This evidence concerns the gene MDM2 and oropharynx cancer.