We have also demonstrated that DIM targets estradiol induced thyroid cancer cell proliferation and metastasis associated events, namely adhesion, migration and invasion, potentially by targeting the metastatic modulators MMP-2/MMP-9 [17], that not only regulate angiogenesis but are also required for degradation of collagen, a major component of extracellular matrices [27,28]. This evidence concerns the gene MMP2 and thyroid cancer.