Furthermore, previous studies in our laboratory, using a mouse monoclonal antibody against NGF (anti-NGF), showed that sustained administration of anti-NGF results in a marked reduction of sprouting and neuroma-like formation by CGRP+, TH+, and NF200+ nerve fibers in the tumor-bearing bone, irrespective of whether the tumor synthesizes NGF [35,46,71]. This evidence concerns the gene TH and neoplasm.