We observed that “Generic Binding Proteins” were enriched in the MapsloBTlo region of the graph and corresponded to weakly connected genes; examples at the lowest end (Maps = 1, BT = 0) include CCM2 (cerebral cavernous malformation 2), CD96, and CDH17 (liver-intestine cadherin). Here, CCM2 is linked to famililal cerebral cavernous malformations.