For instance, microRNA 200 and microRNA 205 can block the suppressive activity of transcriptional repressors of E-cadherin expression, including ZEB1 and ZEB2, thus retaining the epithelial characteristics of breast cancer, whereas lack of microRNA 200 is implicated in the promotion of EMT by up-regulating vimentin expression and diminishing E-cadherin expression in breast cancer cells [65–68]. The gene discussed is VIM; the disease is breast carcinoma.