CDH2 and cancer: The interaction between N-cadherin and PDGFR is known to induce several cellular events important for EMT, including actin reorganization, proliferation, and migration [61], whereas the interaction between N-cadherin and FGFR can prevent the internalization of FGFR upon binding to FGF, resulting in a prolonged MAPK activation as well as increased mobility, MMP secretion, and invasiveness of cancer cells [62].