In database analysis, SOX4 was identified as a target for miR-129-2, and a reporter assay showed that miR-129-2 was a negative regulator of SOX4. Expression of miR-129-2 was verified in 117 cases of endometrial cancer with increased expression of SOX4, and in 68% of the patients SOX4 expression was silenced by methylation. Here, SOX4 is linked to endometrial cancer.