MSH2 and endometrial cancer: Studies of canceration of the endometrium and epimutation of genes have mainly focused on hMLH1, hMSH2, and EPCAM. hMLH1 and hMSH2 are DNA mismatch repair (MMR) genes that have a strong association with endometrial cancer, above that of other MMR genes such as hMSH6 and PMS2 [17].