HGF and cancer: DNMT1 is a well-known target of miR-152, and E2F3, MET, and Rictor have been identified as additional targets [34]. E2F3 is an E2F family transcriptional inhibitor and may be a cancer gene [35]. MET is a gene that encodes a cell-surface receptor for hepatocyte growth factor and a known cancer gene [36]. Rictor is a component of mTORC2 (mTOR complex 2) which directly regulates phosphorylation of Akt and is important in cancer cells [37, 38].