In accordance with a pioneering study on lung cancer and several cancer-derived cell lines, including the HepG2 hepatoma cells [28], epigenetic RASSF1A suppression by hypermethylation of its promoter has been suggested as the main mechanism contributing to RASSF1A downregulation in several cancer types, including HCC [6, 11–24]. This evidence concerns the gene RASSF1 and cancer.