Recent studies have shown that Ras/MAPK pathway is upregulated by multiple factors in HCC in the absence of Ras mutations, including downregulation of the Ras GTPase activating proteins, loss of the ERK inhibitor dual specificity phosphatase 1 (DUSP1), and inactivation of members of the Ras association domain family (RASSF) proteins [6, 9, 10]. The gene discussed is DUSP1; the disease is hepatocellular carcinoma.