As concerns the relationship between RASSF1A promoter hypermethylation and the clinicopathological parameters of HCC patients, it has been shown that RASSF1A epigenetic silencing is significantly associated with the levels of DNA adducts generated by aflatoxin B1 (AFB1), a mycotoxin with hepatocarcinogenic potential produced by the fungus Aspergillus Flavus [16]. Here, RASSF1 is linked to hepatocellular carcinoma.