RASSF1 and neoplasm: In a recent investigation, transfection of the wild-type form of RASSF1A in the QGY-7703 human HCC cell line (expressing low levels of RASSF1A) resulted in fewer and smaller clones, decreased xenograft tumor volume and weight, and led to G1/S arrest both in vitro and in vivo when compared with cells transfected with the empty plasmid [52].