Of note, this pathway is impaired in most human liver cancer specimens, due both to inhibition of RASSF1A [53] and epigenetic silencing of MOAP-1 (Calvisi et al., unpublished results), indicating that loss of RASSF1A-driven apoptosis might be an important molecular event in hepatocarcinogenesis. The gene discussed is RASSF1; the disease is liver cancer.