Furthermore, a recent report indicates that reduced RASSF1A protein expression is related to TNM stage, alpha-fetoprotein levels, and the presence of metastasis, portal vein emboli, capsular infiltration, and multiple tumor nodes, implying that assessment of RASSF1A levels might be helpful also for prognosis prediction in human HCC [24]. The gene discussed is RASSF1; the disease is neoplasm.