IGF1 and Insulin resistance: Observation of the epigenetic profile of the IGF-1 gene from promoter 1 through the 3′ untranslated region (UTR) at day of life (DOL) 21, prior to the onset of insulin resistance, revealed persistent decrease in histone 3 trimethylation of lysine 36 (H3Me3K36) [3], a histone mark that is associated with gene elongation [7–9].