ELISA evaluation of sera collected post- versus pre-infusion revealed that the number of MS subjects receiving any dose of RTL1000 who met the criteria for increased levels of IgG and/or IgM antibody to RTL1000 was not significantly different from the number of antibody positive MS subjects receiving placebo (8/20 versus 2/11, P = 0.262). Here, CD40LG is linked to myeloid sarcoma.