NOS3 and ischemia: In a 90-minute ischemia and 3-hour reperfusion model, miniature pigs were randomly assigned to treatment with TXL (gavaged 1 hour prior to ischemia); TXL plus H-89 (protein kinase-A inhibitor intravenously infused before ischemia); or TXL plus N(omega)-nitro-L-arginine (L-NNA; an eNOS inhibitor, intravenously administered prior to ischemia).