CD4 and disease arising from reactivation of latent virus: Our laboratory is hoping to bridge some of the gaps in our knowledge including (i) why CD4+ and CD8+ T cells from asymptomatic and symptomatic individuals tend to recognize different sets of nonoverlapping HSV Ag epitopes; (ii) Are the epitopes recognized by CD4+ and CD8+ T cells from asymptomatic individuals protective against virus replication, herpetic disease, and/or latent infection?