Our preclinical vaccine trial in “asymptomatic” HLA transgenic (HLA Tg) rabbits showed that immunization with asymptomatic human CD8+ T-cell epitopes from HSV-1 gD induced strong human epitope-specific CD8+ T cell responses and reduced HSV-1 shedding in tears and corneal disease following an ocular challenge [34]. Here, CD8A is linked to corneal disorder.