While colistin is known to induce severe bronchospasm by an unknown mechanism, especially in patients with cystic fibrosis [56], Gómez-Ollés et al. reported a case of OA and rhinitis due to inhalation of colistin in which the subject presented an immediate asthmatic reaction during the SIC [18], the mechanism remaining unknown since the determination of specific IgE was negative. The gene discussed is IGHE; the disease is cystic fibrosis.