However, Salaverria and Siebert [38] pointed out that further studies are needed to clarify: if double hit lymphomas are different from other MYC-positive non-BL cases and if the different types of combinations (DLBCL/BL or DLBCL with BCL2 and/or BCL6 break and IG-MYC or non-IG-MYC fusion) influence the outcome and behavior of these lymphomas. This evidence concerns the gene MYC and lymphoma.