An original approach was presented by Kudo et al. [31], who compared the pre-symptomatic transcriptomes of motor neurons and glial cells between SOD1(G93A) mice and Tau P301L mice, which is a model of neurodegeneration showing typical ALS-like features (including loss of motor neurons, reactive gliosis, and muscle weakness and atrophy), as well as other degenerative signs in the cerebellum, hypothalamus and hippocampus [68]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.