CD82 and neoplasm: Additional genes with putative tumor-suppressor function undergoing epigenetic inactivation by hypermethylation in PCa include KAI1 (a prostate-specific tumor metastasis suppressor gene) [98], inhibin-α (a member of the transforming growth factor–β family of growth and differentiation factors) [99], and DAB2IP, a novel GTPase-activating protein for modulating the Ras-mediated signaling pathway [100].