GJB2 and hearing loss disorder: It is actually reported that connexins 26, 29, 30, 30.3, 31, 32, and 43 codified respectively by GJB2, GJE1, GJB6, GJB4, GJB3, GJB1 and GJA1 genes are involved in human diseases affecting cochlea and some of them (Cx26, Cx30, Cx30.3, Cx31 and Cx43) have been involved too in syndromic form of hearing loss affecting coclea in combination with epidermis [8-10].