CARD8 and posterior cortical atrophy: For example, several independent studies have shown that overexpression of cell survival indicators (e.g., BCL-2, CARD8, IKBKE, PRKCQ, and PIK3CB, AKT3) or down-regulation of cell death markers (e.g., BCL2L14) are associated with more aggressive phenotypes, higher Gleason grade, increased tumor progression, and poor PCA prognosis [6-19].