In terms of disease progression, eleven apoptosis SNPs were modestly associated with a 1.28-1.81 fold increase in the risk of developing aggressive PCA [AKT3 rs10157763 TC & TC + TT; AKT3 rs10927067 AG & AG + AA; AKT3 rs12031994 TC & TC + CC;AKT3 rs2125230 AG & AG + AA; AKT3 rs2125231 AG + AA; AKT3 rs2345994 TC & TC + CC; AKT3 rs4132509 AC & AC + AA; BCL2L14 rs885720 AG & AG + AA; CARD8 rs10405717 TC & TC + TT; IKBKE rs11578093 GG & TG + GG; and RAF1 rs13060691 TG] (p ≤ 0.031), as summarized in Table 3. Here, CARD8 is linked to posterior cortical atrophy.