CASP8 and cancer: In particular, modest cancer risk estimates were observed among 8 apoptosis-related SNPs detected in CASP3, CASP8, CASP9, TP53, NFKB2, and NFKBIA. However, some of these studies were limited by a small sample size, small number of analyzed SNPs, or failure to consider the impact of multiple SNPs on disease susceptibility.