MORC3 and dermatomyositis: The report of NXP-2 as a SUMO (small ubiquitin-like modifier) target with a possible role in SUMO-mediated transcriptional repression [23] is an interesting link with disease mechanisms, because antibodies to SUMO-1 activating enzyme (SAE) have been found in DM [24], and the p155 and Mi-2 antigens could also be involved in transcriptional regulation [25].