In the phase III trial comparing CDA with artemether-lumefantrine [6,5], both CDA and G6PD deficiency were independently associated with the occurrence of a Hb composite safety endpoint comprising the occurrence of a Hb decrease of ≥ 40 g/L or ≥40% vs baseline or Hb <50 g/L or blood transfusion. This evidence concerns the gene GSTM1 and G6PD deficiency.