Based on this study, we had some limitations, such as: 1) the number of homozygous and heterozygous with LH and LHR mutation was small; 2) LH G1052A mutation was not in HWE; 3) The power calculation to fasting glucose level between two LH G1052A genotypes within PCOS group was low. Here, LHCGR is linked to polycystic ovary syndrome.