PCOS had lower frequency of LHR 18insLQ genotype compared with controls (24.9% vs 28%) in a study which there was about 15% lower risk for PCOS per minor allele copy, though the lower LHR 18insLQ frequency was not significant after Bonferronis correction between PCOS and controls [17]. Here, LHCGR is linked to polycystic ovary syndrome.