SIRT1 activation can prevent endothelial senescence during hyperglycemia [81] reduce endothelial atherosclerotic lesions during elevated lipid states [82], and prevent oxidative stress injury in cardiomyocytes through p53 deacetylation and the expression of manganese superoxide dismutase (MnSOD) [83,84]. Here, SIRT1 is linked to Hyperglycemia.