The initial link between the wild-type p53 and TGF-β pathway was proposed in 1991 by Wyllie et al. Inactivation of wild-type p53 by the SV40 virus resulted in loss of response to TGF-β treatment implying that loss of p53 may prelude resistance to the tumour-suppressive effects of TGF-β [55]. Here, TP53 is linked to neoplasm.