AKT1 and neoplasm: Unlike full-length RXRα that resides in the nucleus, tRXRα is cytoplasmic and interacts with the p85α subunit of phosphatidylinositol-3-OH kinase (PI3K) to activate the PI3K/AKT pathway [15], a major survival pathway important for uncontrolled growth of tumor and its progression as well as drug resistance [19].