As shown in Fig. 1, bioluminescence signal reached 3.92±0.79×107 p/s at day 14 after PBS injection in the control group, and significant inhibition of tumor growth was observed in the 60, 80, and 100 mg/kg HSA/TIMP-2 treatment groups: 45.9%, 55.8% and 80.8%, respectively, as compared to control (Fig. 1B; F(4.45) = 13.69, P<0.0001, one-way ANOVA). Here, TIMP2 is linked to neoplasm.