In contrast, Ccl2 deficiency (Ccl2−/−/Crb1RD8/RD8) alone does not significantly influence the retinal degeneration caused by the Crb1RD8/RD8 mutation, although we can not exclude a slight protective effect of it based on the trend for a reduced number of autofluorescent lesions in Ccl2 deficient mice (Ccl2−/−/Crb1RD8/RD8) compared to heterozygous (Ccl2+/−/Crb1RD8/RD8) or wildtype (Ccl2+/+/Crb1RD8/RD8) littermates. Here, CCL2 is linked to retinal degeneration.