Taken together, our study provides evidence for a differential modulatory role of Ccl2 and Cx3cr1 chemokine signalling for the inherited retinal degeneration caused by the Crb1RD8/RD8 mutation and suggests that these two chemokine pathways not only modulate age-related degenerative processes or acute inflammation in the retina, but also contribute to the pathology of inherited retinal degenerations. This evidence concerns the gene CX3CR1 and retinal degeneration.