In recent years, the two chemokine signalling pathways CCL2-CCR2 and CX3Cl1-CX3CR1, have become a major focus of ophthalmological research because of their proposed role in age-related macular degeneration (AMD), one of the most common causes for blindness in the elderly [21], [22]. The gene discussed is CX3CL1; the disease is age-related macular degeneration.