Since BAP1 mutations are known to be more prevalent in high-risk, class 2 OMs, we set out to determine if germline BAP1 mutations could be instructive of a metastatic phenotype by comparing the rates of BAP1 alterations among 50 metastatic OM cases and 50 non-metastatic OM controls matched for gender, age, largest tumor diameter (LTD) and ciliary body involvement (Figure 1A; Table S1). The gene discussed is BAP1; the disease is neoplasm.