To determine which of these receptors was responsible for the autocrine effects of VEGF-D, we analysed both mRNA and protein expression of these receptors in 468GFP and 468LN cells, along with other human breast cancer cell lines: MDA-MB-231 [9] and MCF7-COX-2 (M Majumder 2011, unpublished) served as positive controls for VEGF-R2 and VEGF-R3 expression. This evidence concerns the gene MT-CO2 and breast cancer.