VEGF-D, which can bind to both VEGFR-2 and VEGFR-3, was shown to be capable of inducing both angiogenesis and lymphangogenesis leading to lymphatic metastasis in NOD/SCID mice transplanted with a tumor cell line forced to over-express VEGF-D, but not VEGF-A. Here, FLT4 is linked to neoplasm.