Evidence for a link between the EYAs and cardiovascular development has been growing; mutation of EYA4 is associated with dilated cardiomyopathy [17], human EYA1 mutations are associated with cardiac defects [18], there are alterations in cardiovascular function in Eya3 mutant mice [19], and Six1-/-Eya1-/- mutant mice exhibit multiple vascular anomalies [20]. The gene discussed is EYA1; the disease is dilated cardiomyopathy.