Interestingly, it was observed that, in de novo gefitinib-resistant LoVo colorectal cancer cells, which are defective in their ability to produce mature IGF-1R and predominantly express insulin receptor-isoform A (InsR-A), a close family member of the IGF-1R, gefitinib enhances insulin receptor activity and levels of downstream activated Akt [55]. The gene discussed is AKT1; the disease is colorectal cancer.