Moreover, using antibodies against S473 and T308, two sites of Akt phosphorylation, Akt activation was shown to be selective for NSCLC versus normal tissue, and phosphorylation of Akt at both sites was shown to be a better predictor of poor prognosis in NSCLC than phosphorylation at S473 alone [34]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.