MCAM and melanoma: Overexpression of METCAM in melanoma cells mostly have a positive effect on the metastasis of human melanoma cell lines in immunodeficient mice (both athymic nude and SCID mice) [3, 20], mouse melanoma cell lines in syngeneic mice [7, 21], and a human prostate cancer cell line, LNCaP, in nude mice [7, 13, 36].