Though METCAM has not been shown to be a substrate of CK2, which has been shown to phosphorylate other CAMs, such as CD44, E-cadherin, L1-CAM, and vitronectin, it is also likely that CK2 may be able to phosphorylate METCAM [46] and link it to AKT to affect the proliferation, survival, and other tumorigenesis-related functions of tumor cells [47]. This evidence concerns the gene AKT1 and neoplasm.