Shih et al. showed that METCAM was not expressed in MCF-7 cell line [24], and they showed that the overexpression of huMETCAM in MCF-7 cells suppressed tumor formation of the cells in SCID mice, as shown in Figure 6, suggesting that METCAM is a possible tumor suppressor in breast cancer [24]. The gene discussed is MCAM; the disease is breast cancer.