We also carried out animal studies by using another human ovarian cancer cell line, SK-OV-3 and found that overexpression of METCAM suppressed tumorigenesis of SK-OV-3 cells at both nonorthotopic, subcutaneous sites, as well as an orthotopic site (the intraperitoneal cavity) [34], as shown in Figure 11. Here, MCAM is linked to ovarian cancer.