Therefore, we sought to define its role, as correlated with microvessel density, in Paget's disease of the vulva and the breast.Microvessels were analysed using anti-von Willebrand factor antibody in 105 cases of Paget's disease of the vulva and the breast comprising 71 cases of Paget's disease of the vulva, including 8 cases with invasive disease, and 34 cases of Paget's disease of the breast. Here, VWF is linked to mammary Paget disease.