Hence, although myeloid cells are largely refractory to productive HIV-1 infection due to the presence of cellular restriction factors such as the recently identified SAMHD1 [19],[20], the sialyllactose driven trans-infection process characterized here in mDCs seems to exploit a pre-existing cellular-trafficking machinery that avoids the activation of these intrinsic immune pathways. This evidence concerns the gene SAMHD1 and HIV-1 infection.