Nevertheless, as it has been extensively described in this paper, the NK-1 receptor constitutes an important network for signal transduction in the cancer microenvironment and NK-1 receptor antagonists exert three harmonizing mechanisms: first, they have an antiproliferative action due to the inhibition of tumor cell growth and induction of apoptosis; second, they inhibit angiogenesis in the tumor mass; third, they block the migration of tumor cells and thereby inhibit invasion and metastasis. The gene discussed is TACR1; the disease is cancer.