NFKB1 and Parkinson disease: Given the importance of the canonical form of transcription factor NF-κB in both the production of the components of the oxidative stress response (p47 and p67 are regulated by NF-κB), and in the regulatory effects of ROS in activating microglia (NF-κB controls ERK activity induced by LPS signaling, Figure 2), inhibitors of the canonical pathway of NF-κB should provide strong evidence of the role of oxidative stress responses in PD.