Our results demonstrate that human melanoma L1CAM accumulates cancer-associated glycan structures, among which are β1-6-branched complex-type glycans with or without N-acetyllactosamine repeats, fucose α1-3-linked to GlcNAc in the antenna (Lex), low-mannose structures, as well as GlcNAc-terminated complex-type glycans. The gene discussed is L1CAM; the disease is cancer.