Immunohistochemical staining of these two cell types can aid in the diagnosis of ganglioneuroma, with the Schwann cells being strongly positive for S100 and the ganglion cells being immunoreactive to synaptophysin, CD56, neuron-specific enolase, and neurofilament proteins as seen in Figure 1D of our case. This evidence concerns the gene NCAM1 and ganglioneuroma.